This guide is meant to help recipients in the administration of USG Department of Health and Human Services (HHS) awards. The regulations cover the general provisions and the pre-award, post-award and after-theaward requirements for USG awards. These regulations have a flow-down effect on the sub-recipients of the HHS awards. In this guide, key regulations applicable to HHS awards have been outlined. Users of this guide are reminded that the guide does not comprehensively cover all the requirements, and are encouraged to make references to the respective regulations for more details. The applicable regulations are annexed to this guide.