When the first PEPFAR programs launched in 2004, many people did not believe it was possible to deliver high-quality, sustainable HIV treatment in low-resource settings. Over the next nine years, AIDSRelief and other PEPFAR partners exceeded all expectations, delivering HIV care and treatment to more than 700,000 people in 10 countries, including nearly 400,000 who enrolled on antiretroviral therapy. This final report on AIDSRelief outlines key outcomes and lessons learned. It describes approaches and methods that contributed to the initiative's success.